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Johns Hopkins Center for Psychedelic and Consciousness Research They propose that the marked α power decreases observed with psilocybin were likely due to interference with the intrinsic α oscillations of deep-layer pyramidal neurons via stimulation of the 5-HT2A receptor. To test the potential efficacy of R-DOI to treat a human inflammatory disease, the Nichols group (Nau et al., 2015) assessed the effects of R-DOI in a mouse model of allergic asthma. In this model, BALB/c mice were sensitized with chicken egg white protein [ovalbumin ] to generate an IgE allergic response. To induce asthma-like symptoms after sensitization, the mice were then exposed to nebulized OVA (nose-only). This treatment results in the mice developing pulmonary inflammation, airways hyperresponsiveness, eosinophilia, and mucus hyperproduction, each representative of hallmark symptoms of human allergic asthma. Remarkably, R-DOI at doses as low as 0.01 mg/kg administered nose-only prior to OVA administration ...